Therapeutic and screening methods using C3a receptor and C3a

Details Therapeutic and screening methods using C3a receptor and C3a Therapeutic and screening methods using C3a receptor and C3a

1997-06-16

1999-08-24

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 721, 436501, 436821, G01N 33566, G01N 3358

Patent

active

059424052

ABSTRACT:
Human C3a Receptor polypeptides and DNA (RNA) encoding such C3a Receptor and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such C3a Receptor for the treatment of inflammatory and auto-immune disorders, among others. Antagonists against such C3a Receptor and their use as a therapeutic to treat inflammatory and auto-immune disorders, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the C3a Receptor and for detecting altered levels of the polypeptide in a host.

REFERENCES:
patent: 5861272 (1999-01-01), Li
Crass, T., et al., "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells", Eur. J. Immunol., 26: 1944-1950, (1996).
Roglic, A., et al., "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure", Biochimica et Biophysica Acta, 1305: 39-43 (1996).
Ames, Robert S., et al., "Molecular cloning and characterization of the human anaphylatoxin C3a receptor", J. Biolog. Chem., 271(34): 20231-20234 (1996).

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