cis-4,5-Didehydro-16-phenoxy-PGE.sub.1 compounds

Details cis-4,5-Didehydro-16-phenoxy-PGE.sub.1 compounds cis-4,5-Didehydro-16-phenoxy-PGE.sub.1 compounds

1978-04-28

1980-07-15

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562463, C07L17700

Patent

active

042129850

ABSTRACT:
The disclosure includes novel compounds which differ from the known prostaglandins PGF.sub.2.alpha., PGF.sub.2.beta., PGE.sub.2, PGA.sub.2, and PGB.sub.2 in that the carbon-carbon double bond in the carboxyl-terminated chain of the novel compounds is in the 4,5-position rather than in the 5,6-position, and in that there is a phenoxy or substituted phenoxy group in the other chain of the novel compounds. These novel compounds are useful for a variety of pharmacological purposes, including abortion, labor induction, and reduction of gastric secretion.

REFERENCES:
Chem. Abst. 88:74115C Neth. Apl. 7513108.
Chem. Abst. 86:16347e Ger. Offen. 2,460,990.

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