Process for preparing griseolic acid derivatives

Details Process for preparing griseolic acid derivatives Process for preparing griseolic acid derivatives

1986-04-25

1988-11-08

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

536 24, 536 26, C07D 4734, A61K 3152

Patent

active

047835320

ABSTRACT:
Griseolic acid and dihydrodesoxygriseolic acid derivatives having an alkyl or aralkyl group as a substituent on the amino group at the 6-position are prepared by reacting the unsubstituted compound with a compound R.sup.7 -X (where R.sup.7 is alkyl or aralkyl and X is halogen or sulfonyloxy). The group first substitutes and quaternizes the 1-nitrogen atom. The compound is then subjected to an appropriate combination of temperature and pH to cause ring cleavage, rearrangement and ring closure involving the 6-amino group and this quaternized 1-nitrogen to give a 6-alkylamino or 6-aralkylamino derivative.

REFERENCES:
patent: 4460765 (1984-07-01), Naitr et al.
patent: 4634706 (1987-01-01), Kaneko et al.

Affiliated with

Also associated with

Rating

Process for preparing griseolic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing griseolic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing griseolic acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-464642