Method for the production of 9-(2-O-acyl-.beta.-D-arabinofuranos

Details Method for the production of 9-(2-O-acyl-.beta.-D-arabinofuranos Method for the production of 9-(2-O-acyl-.beta.-D-arabinofuranos

1977-05-23

1980-07-15

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435197, 435839, 435896, 435897, 435886, 435872, 435863, 435822, C12P 1932

Patent

active

042129419

ABSTRACT:
9-(2-O-Acyl-.beta.-D-arabinofuranosyl)adenine compounds and their production by enzymatic removal of the 3-O-acyl and 5-O-acyl groups of a 9-(2,3-di-O-acyl-.beta.-D-arabinofuranosyl)adenine compound or a 9-(2,3,5-tri-O-acyl-.beta.-D-arabinofuranosyl)adenine compound. The monoester compounds are useful as antiviral agents. The compounds are water-soluble and lipophilic, thereby being adaptable to a wide variety of pharmaceutical formulations.

REFERENCES:
patent: 3304236 (1967-02-01), Nuesch
patent: 3651045 (1972-03-01), Haskell et al.

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