Recombinant poxvirus compositions and methods of inducing immune

Details Recombinant poxvirus compositions and methods of inducing immune Recombinant poxvirus compositions and methods of inducing immune

1995-06-02

1999-08-24

Crouch, Deborah

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4241991, 424 932, 4353201, 435456, A61K 39275, A61K 3912, A61K 4800, C12N 1500

Patent

active

059422351

ABSTRACT:
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: human tumor necrosis factor; nuclear phosphoprotein p53, wildtype or mutant; human melanoma-associated antigen; IL-2; IFN.gamma.; IL-4; GMCSF; IL-12; B7; erb-B-2 and carcinoembryonic antigen. The recombinant viruses and gene products therefrom are useful for cancer therapy.

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