Epoxides useful as antiallergic agents

Details Epoxides useful as antiallergic agents Epoxides useful as antiallergic agents

1986-12-29

1988-11-08

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549414, 549512, 549554, A61K 31335, C07D30304, C07D30312

Patent

active

047834838

ABSTRACT:
Alkenes of the formula (I) and epoxides (II) used to make them are useful as anti-inflammatory and antiallergic pharmaceuticals: ##STR1## wherein R.sup.1 =H or CH.sub.3 ; R.sup.2 =phenyl, substituted phenyl, benzyl or a cysteinyl moiety; R.sup.4 and R.sup.5 =alkyl; n=O or 1; and R.sup.3 is as described.

REFERENCES:
patent: 4513005 (1985-04-01), Baker et al.
Science, "The Leukotrienes in Allergy and Inflammation", vol. 215, pp. 1380-1383, (1982).
Chest, "Leukotrienes and Other Lipid Mediators of Asthma", Robert A. Lewis, M.D., vol. 87, No. 1, pp. 5S-10S (1985).
Drugs, "Leukotrienes in Disease Implications for Drug Development", G. A. Higgs and S. Moncada, vol. 30, pp. 1-5, (1985).
ACTA Physiologica Scandinavica, "Pulmonary Effects of Leukotrienes", Sven-Erik Dahlen, Stockholm 1983, Supplementum 512, pp. 4-6 and 37-38.

Affiliated with

Also associated with

Rating

Epoxides useful as antiallergic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Epoxides useful as antiallergic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Epoxides useful as antiallergic agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-464317