Treatment of arthritis, including rheumatoid arthritis, with the

Details Treatment of arthritis, including rheumatoid arthritis, with the Treatment of arthritis, including rheumatoid arthritis, with the

1987-03-26

1990-03-06

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424633, 424639, 424647, 424653, 424655, 424689, 600 3, A61K 4300, A61N 512

Patent

active

049064509

ABSTRACT:
The radionuclide Tin, Sn-121 in a carrier hydroxide aggregate is disclosed for the treatment of arthritis and, in particular, rheumatoid arthritis of the hands, the interphalangeal joints of the fingers and the metacarpal joints of the hand.
The radioactive compound disclosed preferably has a particle size of <90 microns. The beta energy emission associated with Tin, Sn-121 has an energy of 0.38 meV. There are no gamma photons emited during the decay of Tin, Sn-121 to stable Antimony Sb-121. The half life of Tin, Sn-121 is 27.06 hours.
The method of preparation of the compound is disclosed along with the method of administration to the patient in need thereof.

REFERENCES:
patent: 4511551 (1985-04-01), Cardarelli et al.
patent: 4533541 (1985-08-01), Srivastava et al.
Erdar et al. "J. Inorg. Nucl. Chem.", 1968, 30(8) pp. 1985-1993 [Chemical Abstracts vol. 68, 1968.]
Sledge et al, "Expermental Radiation", Arthritis and Rheumatism, vol. 20, No. 7, Sep.-Oct. 1977, 1334-1342.

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