Process for the preparation of optionally substituted 2,3-indoli

Details Process for the preparation of optionally substituted 2,3-indoli Process for the preparation of optionally substituted 2,3-indoli

1978-12-04

1980-07-15

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032611R, C07D20938, C07D20936

Patent

active

042128048

ABSTRACT:
An improved process for the preparation of optionally substituted 2,3-indolinediones which are useful as intermediates in the preparation of compounds having pharmacological activity which comprises reacting a 3,1-benzoxazine with an alkali or alkaline earth metal cyanide or a tetra-(C.sub.1-4) alkylammonium cyanide to obtain a 2-imino-3-indolinone, which is then subjected to hydrolysis.

REFERENCES:
S. Kadin et al., Chemical Abstracts 85:151986y (1977), A Convenient Synthesis of 2-Amino-4-Hydroxy Quinolines.
A. R. Katritzky et al., Advances in Heterocyclic Chemistry, vol. 18, pp. 2-12, (1975).
W. C. Sumpter et al., Heterocyclic Compounds with Indole and Carbazole Systems, pp. 110-116, (1954).

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