Decahydroquinolines, pharmaceutical compositions and methods of

Details Decahydroquinolines, pharmaceutical compositions and methods of Decahydroquinolines, pharmaceutical compositions and methods of

1978-03-08

1979-11-06

Wheeler, David

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546160, 546161, 546162, A61K 3147, C07D21544

Patent

active

041736362

ABSTRACT:
The invention relates to decahydroquinoline derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 represents an alkyl or alkoxy group, a lower dialkylamino group, an optionally substituted phenyl group, a heterocyclic group; R.sup.2 represents an alkyl group, an optionally substituted phenyl group, a naphthyl group, an unsaturated heterocyclic group, an aralkyl group or an alicyclic group; and R.sup.3 represents a substituted furyl group, an aralkyl group or a group represented by the general formula: ##STR2## wherein A represents an alkylene group; Y represents an oxygen or sulphur atom, a carbonyl, carbonyl-hydroxyimino, carbonyl-hydrazono or sulphoxide group, or a group; ##STR3## n is O or an integer of from 1 to 4, with the proviso that when n is O, Y represents a carbonyl group; and R.sup.4 and R.sup.5, which are identical or different, each represent hydrogen, a halogen atom or a methyl, methoxy or acetyl group.
Certain compounds of formula I have been found to possess useful analgesic properties while others have been found to be potentially useful in the treatment of high blood pressure.

REFERENCES:
patent: 3455929 (1969-07-01), Belleau et al.
patent: 3882129 (1975-05-01), Prost et al.

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