Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols a

Details Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols a Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols a

1979-04-30

1980-05-20

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546133, A61K 31445, C07D45302

Patent

active

042039894

ABSTRACT:
The present invention provides Diaryl-(1-azabicyclo [2.2.2]octan-2-yl)alkanols of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R is a cycloalkanol having 4-8 carbon atoms, an alkanol having 1-2 carbon atoms, or a radical of the formula ##STR2## wherein R.sub.1 and R.sub.2 are each H or a C.sub.1 -C.sub.5 alkyl, and R.sub.3 is H or an acyl of the formula ##STR3## wherein R.sub.4 is H or a C.sub.1 -C.sub.4 alkyl. These alkanols are useful as antidiarrheal agents.

REFERENCES:
patent: 3917615 (1975-11-01), Adelstein
patent: 3998832 (1976-12-01), Adelstein et al.
patent: 4013667 (1977-03-01), Yen
patent: 4017491 (1977-04-01), Adelstein
patent: 4086234 (1978-04-01), Dryden et al.
patent: 4125531 (1978-11-01), Yen
Adelstein, G., et al., J. Med. Chem., 19(10), 1221-1225 (1976).

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