Thiazolylacetamido compounds

Details Thiazolylacetamido compounds Thiazolylacetamido compounds

1978-04-17

1980-05-20

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 21, 544 22, 544 27, 424246, 548187, 548195, A61K 31545, C07D27744

Patent

active

042038995

ABSTRACT:
Novel cephem compounds of the formula; ##STR1## wherein R.sup.1 represents amino or hydroxyl group which may be protected, R.sup.2 represents amino or hydroxyl group or a group convertible into these groups, R.sup.3 represents hydrogen or methoxy group or a group convertible into methoxy group, R.sup.4 represents hydrogen or a residue of a nucleophilic compound and R.sup.8 represents hydrogen or a halogen, or a pharmaceutically acceptable salt or ester thereof, have strong antibiotic properties against a wide variety of microorganisms including gram-positive bacteria as well as gram-negative ones, especially by oral administration and can be used as therapeutic agent for various bacterial infections of animals including human beings.
Also disclosed are novel thiazolylacetic acid compounds of the formula: ##STR2## wherein R.sup.1 represents amino, protected amino, hydroxyl or protected hydroxyl, R.sup.2 represents amino, protected amino, hydroxyl, protected hydroxyl or the group ##STR3## represents a group of the formula ##STR4## wherein R.sup.5 represents hydroxyl or lower alkoxy and R.sup.8 represents hydrogen or a halogen, or a salt, an ester or a reactive derivative thereof, and to processed for preparing these compounds. These latter compounds are useful as intermediates in the preparation of the novel cephem compounds.

REFERENCES:
patent: 3234218 (1966-02-01), Schmidt et al.
patent: 3631055 (1971-12-01), Posselt et al.
patent: 3755347 (1973-08-01), Guillot et al.
patent: 3948925 (1976-04-01), Perronnet et al.
patent: 4008246 (1977-02-01), Ochiai et al.
Garraway, "Chemical Abstracts," vol. 74, 1971, Col. 75415a.

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