Antihyperlipidemic and antiatherosclerotic compounds and composi

Details Antihyperlipidemic and antiatherosclerotic compounds and composi Antihyperlipidemic and antiatherosclerotic compounds and composi

1990-02-09

1991-03-12

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514454, 514455, 544 26, 544 27, 544388, 544392, 549394, A01N 4314, A01N 4316, C07D33508, C07D31182

Patent

active

049993739

ABSTRACT:
Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N'-arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA: cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis.

REFERENCES:
patent: 4387105 (1983-06-01), DeVries et al.
patent: 4387106 (1983-06-01), DeVries et al.
patent: 4397868 (1983-08-01), DeVries
patent: 4473579 (1984-09-01), DeVries et al.
patent: 4623662 (1986-11-01), DeVries
Chemical Abstracts, vol. 109(11), No. 927298, 1988, "Preparation and Properties of Quaternary N-Allytheteroammonium Salts".
Chemical Abstracts, vol. 79(17), No. 105040xa, 1973, "Hydroxylamines 62.Acylation of Xanthylhydroxyamines".
Chemical Abstracts, vol. 52(17)#17174e.

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