Manufacture of oxazolidines by the alkoxylation of imines

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D26304

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046772081

ABSTRACT:
N-substituted mono or bis-oxazolidines may be manufactured by reacting an alkylene oxide at alkoxylating conditions with a mono-imine of the general formula: ##STR1## or a bis-imine of the general formula: ##STR2## wherein R is a linear or branched alkyl, aryl, aralkyl, alkylenyl or aryllenyl group having 1-22 carbon atoms, and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different, and are selected from the group including H--, methyl, ethyl, isobutyl, isoamyl, or phenyl. The oxazolidine may thereafter be cleaved with water, preferably slightly acidified, to produce the monoethoxylated amine.

REFERENCES:
patent: 3743626 (1973-07-01), Emmons
patent: 3897362 (1975-07-01), McCoy
patent: 3912691 (1975-10-01), Emmons
Fokin et al, Izvestiya Akademii Nauk SSSR Seriya Kimicheskaya, vol. 8, 1982, pp. 1872-1876.
Fokin et al, Chem. Abst. 98-4493j.

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