Production of human pluripotent granulocyte colony-stimulating f

Details Production of human pluripotent granulocyte colony-stimulating f Production of human pluripotent granulocyte colony-stimulating f

1989-03-06

1991-03-12

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 695, 435 703, 435 712, 435 91, 4351723, 4353201, 536 27, 530350, 935 13, 935 18, 935 27, 935 32, 935 41, 935 56, 935 58, 935 60, 935 70, 935 73, 935 81, C12P 2106, C12P 2102, C12P 2104, C12P 1234, C12N 1500, C12H 1512, C12K 300

Patent

active

049992910

ABSTRACT:
Disclosed are novel polypeptides possessing part or all of the primary structural conformation and one or more of the biological properties of a mammalian (e.g., human) pluripotent granulocyte colony-stimulating factor ("hpG-CSF") which are characterized in preferred forms by being the product of procaryotic or eucaryotic host expression of an exogenous DNA sequence. Sequences coding for part or all of the sequence of amino acid residues of hpG-CSF or for analogs thereof may be incorporated into autonomously replicating plasmid or viral vectors employed to transform or transfect suitable procaryotic or eucaryotic host cells such as bacteria, yeast or vertebrate cells in culture. Products of expression of the DNA sequences display, e.g., the physical and immunological properties and in vitro biological activities of isolates of hpG-CSF derived from natural sources. Disclosed also are chemically synthesized polypeptides sharing the biochemical and immunological properties of hpG-CSF.

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