Substituted-3-azabicyclo[3.1.1]heptane-2,4-diones useful for tre

Details Substituted-3-azabicyclo[3.1.1]heptane-2,4-diones useful for tre Substituted-3-azabicyclo[3.1.1]heptane-2,4-diones useful for tre

1985-06-20

1987-06-30

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546183, 560123, 560147, 562505, A61K 31435, C07D22122

Patent

active

046771298

ABSTRACT:
1-phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

REFERENCES:
patent: 2673205 (1954-03-01), Hoffmann et al.

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