Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1985-10-31
1987-06-30
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514869, 514893, 514907, A61K 31195
Patent
active
046771212
ABSTRACT:
Muscle protein breakdown or degradation may be reduced or inhibited in mammals, particularly humans recovering from surgery or suffering from a muscle wasting disorder, by administering daily doses of alpha-ketoisocaproic acid (ketoleucine) or an appropriate salt of the acid. Seventy millimoles per day of sodium alpha-ketoisocaproate administered for five days after major abdominal surgery was found to significantly reduce urinary 3-methylhistidine/creatinine, which is a measure of muscle protein breakdown, and thereby to improve nitrogen balance.
REFERENCES:
patent: 4100160 (1978-07-01), Walser I
patent: 4100161 (1978-07-01), Walser II
patent: 4100293 (1978-07-01), Walser III
patent: 4228099 (1980-10-01), Walser
patent: 4296127 (1981-10-01), Walser
patent: 4320146 (1982-03-01), Walser
Stewart, Peter M., Walser, Mackenzie and Drachman, Daniel B., "Branched--Chain Ketoacids Reduce Muscle Protein Degradation in Duchenne Muscular Dystrophy", Muscle & Nerve, Mar. 1982, pp. 197-201.
Mitch et al., Nitrogen Sparing Induced by Leucine Compared with that Heat Induced by its Keto Analog, .alpha.-Ketoisocaproate, J. Clin. Inv. 67:553-12, 1981.
Tischler et al., Relationship of Leucine Catabolism to its Regulatory Effectsion Protein Turnover in Muscle, Fed Proc. 39:1682, 1980.
Sapir Daniel G.
Stewart Peter M.
Walser Mackenzie
Brown Johnnie R.
Rollins Jr. John W.
The Johns Hopkins University
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