Antihypertensive chroman derivatives

Details Antihypertensive chroman derivatives Antihypertensive chroman derivatives

1984-10-12

1987-06-30

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549404, 549345, A61K 3135, C07D31102

Patent

active

046771166

ABSTRACT:
Compounds of formula (I) ##STR1## wherein: either one of R.sub.1 and R.sub.2 is hydrogen and the other is selected from the class of C.sub.1-6 alkylcarbonyl, C.sub.1-6 alkoxycarbonyl, C.sub.1-6 alkylcarbonyloxy, C.sub.1-6 alkylhydroxymethyl, nitro, cyano, chloro, trifluoromethyl, C.sub.1-6 alkylsulphinyl, C.sub.1-6 alkylsulphonyl, C.sub.1-6 alkoxysulphinyl, C.sub.1-6 alkoxysulphonyl, C.sub.1-6 alkylcarbonylamino, C.sub.1-6 alkoxycarbonylamino, C.sub.1-6 alkylthiocarbonyl, C.sub.1-6 alkoxythiocarbonyl, C.sub.1-6 alkylthiocarbonyloxy, C.sub.1-6 alkylthiolmethyl, formyl or aminosulphinyl, aminosulphonyl or aminocarbonyl, the amino moiety being optionally substituted by one or two C.sub.1-6 alkyl groups, or C.sub.1-6 alkylsulphinylamino, C.sub.1-6 alkylsulphonylamino C.sub.1-6 alkoxysulphinylamino or C.sub.1-6 alkoxysulphonylamino or ethylenyl terminally substituted by C.sub.1-6 alkylcarbonyl, nitro or cyano, or --C(C.sub.1-6 alkyl)NOH or --C(C.sub.1-6 alkyl)NNH.sub.2, or one of R.sub.1 and R.sub.2 is nitro, cyano or C.sub.1-3 alkylcarbonyl and the other is methoxy or amino optionally substituted by one or two C.sub.1-6 alkyl or by C.sub.2-7 alkanoyl;

REFERENCES:
patent: 3103520 (1963-09-01), Zaugg et al.
patent: 4446113 (1984-05-01), Evans et al.
patent: 4568692 (1986-02-01), Evans
patent: 4571406 (1986-02-01), Evans et al.
Lap et al., Aust. J. Chem. 1979, 32 pp. 619-636.
Chem. Abst. vol. 77, 88182j (1972).

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