Process for producing 2,2'-o-cyclonucleosides nucleosides, and a

Details Process for producing 2,2'-o-cyclonucleosides nucleosides, and a Process for producing 2,2'-o-cyclonucleosides nucleosides, and a

1994-09-27

1997-03-11

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 285, 536 2852, C07H 1906, C07H 19067

Patent

active

056102925

ABSTRACT:
A novel process is provided for producing a nucleoside, such as cytarabine, or a nucleoside analogue, comprising the step of reacting 2,2'-O-cyclonucleoside or an analogue thereof with an amine. Preferably, the process is conducted in the presence of an aqueous solvent. A novel process for the production of the precursor 2,2'-O-cyclonucleoside compounds and pharmaceutically acceptable salts thereof is also provided which comprises reacting a 2,3'-O-diaikylstannylene nucleoside compound with an amine in the presence of a sulfonyl compound. Cytarabine is a known antineoplastic and antiviral agent.

REFERENCES:
patent: 4652554 (1987-03-01), Chwang
patent: 5399682 (1995-03-01), Karimian et al.
Hamamura et al. J. Med. Chem. 19(5) (1976), pp. 667-674.
Divakar et al. J. Chem. Soc Perkins Trans I, (1982) (5), pp. 1171-1176.
Gosselin et al. J. Med. Chem. 29 (1986), pp. 203-213.
D. Wagner et al. "Preparation & synthetic utility . . . " The Jour. of Organic Chemistry, vol. 39 No. 1, Jan. 1974, pp. 24-30.
Chemical Abstracts, vol. 86 No. 16, 18 Apr. 1977 #121712t. Columbus, Ohio, p. 583.
H. P. M. Fromageot et al. "N.sup.4 O.sup.3', O.sup.5' -triacetyl . . . " Tetrahedron Letters, No. 29, 1966, Pergamon Press Ltd. (GB), pp. 20-25.

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