DNA's encoding natural killer cell enhancing factor

Details DNA's encoding natural killer cell enhancing factor DNA's encoding natural killer cell enhancing factor

1994-08-31

1997-03-11

Ulm, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530380, 435 696, C12N 1512

Patent

active

056102860

ABSTRACT:
Recombinant DNA molecules comprising a DNA sequence encoding either NKEF (Natural Killer Enhancing Factor) A or B or their amino acid sequence variants. Essentially pure natural killer enhancing factor comprising the amino acid sequence of NKEF A or B or their amino acid sequence variants. Compositions of matter for use in enhancing the activity of natural killer cells; the composition comprising an anchor moiety to which is linked either NKEF A or B or their amino acid sequence variants. Methods for enhancing the in vivo activity of natural killer cells; the methods comprising introducing in vivo a sufficient amount of either NKEF A or B or their amino acid sequence variants linked to an anchor moiety. In a method for inducing leukocyte activation and proliferation wherein the leukocytes are treated with a cytokine the improvement comprising treating the leukocytes with the cytokine in the presence of NKEF A or B or their amino acid sequence variants.

REFERENCES:
Shau et al. (1994, Jun.) Immunogenetics vol. 40, pp. 129-134.
Prosperi et al. (1993) J of Biol. Chem. vol. 268, No. 15 pp. 11050-11056.

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