Inhibition of metastasis in patients having cancer with pyridylo

Details Inhibition of metastasis in patients having cancer with pyridylo Inhibition of metastasis in patients having cancer with pyridylo

1995-01-03

1997-03-11

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514376, A61K 3144, A61K 3142

Patent

active

056101716

ABSTRACT:
This invention is directed to pyridinyloxazole-2-ones which are useful in inhibiting metastasis in patients having cancer. The pyridinyloxazole-2-ones act to inhibit protein kinase C and thereby modulate metastasis in patients having cancer.

REFERENCES:
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patent: 4866085 (1989-09-01), Schnettler et al.
patent: 5182293 (1993-01-01), Sunkara
B. Krieg, et al., 4-Oxazolin-2-One Aus N-(2-Oxoalkyl)-1-Imidazolcarboxamiden, Liebigs Ann. Chem., 1862-1872 (1976).
Robinson et al, Biosis Abstract 91:94846 of J. Pharmacol. Exp. Ther. 255(3):1392-1398 (1990).

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