Single pot process for making a fluoroanthranilic acid

Details Single pot process for making a fluoroanthranilic acid Single pot process for making a fluoroanthranilic acid

1989-08-28

1990-09-04

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562456, 562458, C07D20948

Patent

active

049546392

ABSTRACT:
Disclosed is a method of making ionized fluoroanthranilic acid from a fluorophthalic compound in a single pot process without isolating any intermediate product. A composition is prepared which comprises an aqueous solution of water, a fluorophthalic compound selected from the group consisting of ##STR1## and mixtures thereof, where "n" is 1 to 4, at a concentration of about 5 to about 30 percent by weight based on the water weight, and about 1 to about 1.5 equivalents of hydroxylamine or a mineral acid salt thereof. The pH of the composition is maintained at at least about 11 and the temperature of the composition is maintained at at least about 90.degree. C. The unionized form of the acid is made by cooling below 50.degree. C. and lowering the pH to between about 4 and about 5. Also disclosed are the intermediate compounds, fluoro-N-hydroxyphthalimides, and a method of making them.

REFERENCES:
patent: 3832364 (1974-08-01), Coulson
patent: 3847974 (1974-11-01), Sturm et al.
patent: 4232459 (1980-11-01), Kilpper et al.
patent: 4374266 (1983-02-01), Fifolt et al.
patent: 4521616 (1985-06-01), Fifolt
An article by Villiger, V. in Chem. Ber., vol. 1909, pp. 3529-3549.

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