Bicyclic precursors for the preparation of biotin

Details Bicyclic precursors for the preparation of biotin Bicyclic precursors for the preparation of biotin

1987-07-13

1988-03-22

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49504

Patent

active

047329882

ABSTRACT:
A novel process is described for preparation of biotin comprising preparation of substituted 3H, 5H-imidazo[1, 5c]tetrahydro thiazoles by contacting the boron trifluoride adduct of an appropriate thiazoline with the metallic derivative of an ester enolate, reducing the ester, hydrolyzing the thiazolidine moiety and hydrolyzing or oxidizing the resultant compound. Intermediates obtained in the preparation of biotin by the above process and alternate procedures for preparing said intermediates are also presented. A novel process for preparation of d-biotin is also given.

REFERENCES:
patent: 3983134 (1976-09-01), Matsui et al.
patent: 4584191 (1986-04-01), Hostettler et al.

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