Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1994-07-19
1997-03-11
Scheiner, Toni R.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436807, 436 80, G01N 3353
Patent
active
056100779
ABSTRACT:
A process for carrying out a specific binding assay by reacting (a) a sample under assay for the possible presence of a substance being tested for, (b) a specific binding partner for the substance being tested for, immobilised on a solid support, and (c) a specific binding partner for the substance being tested for which is conjugated to a detectable marker, to thereby form a complex by reacting between whatever quantities are present of the substance being tested for in (a) with reagents (b) and (c). The marker is immobilised to the support via the substance being tested for, and is detected or assayed as an index of the quantity present in the sample (a) of any of the substance. The reaction ingredients (a), (b) and (c) are all mixed in a single step for reaction in a single reaction liquid. Competitive interference between the binding reactions of the substance being tested for and reagents (b) and (c) is avoided by use of monoclonal antibodies of narrow and different, non-interfering specificity, reaction reagent (b) is immobilized on the surface of a displacer body.
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Davis Paul J.
Porter Philip
Scheiner Toni R.
Unilever Patent Holdings B.V.
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