Enzymatic RNA molecule targeted against Hepatitis C virus

Details Enzymatic RNA molecule targeted against Hepatitis C virus Enzymatic RNA molecule targeted against Hepatitis C virus

1994-01-13

1997-03-11

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435 6, 435 9131, 4353201, 435325, 435366, 536 231, 536 232, 536 245, 514 44, C12N 1585, C12Q 168, A61K 4800

Patent

active

056100540

ABSTRACT:
An enzymatic RNA molecule which specifically cleaves RNA of a hepatitis C virus.

REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5168053 (1992-01-01), Altman et al.
Stull et al. Pharm. Res. 12:465 (1995).
Barinaga, Science 262:1521-1514, 1993.
Johnston et al., Science 260:12861293.
Kim et al., "Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena", 84 Proc. Nat. Acad. of Sci. USA 8788, 1987.
Haseloff et al., 234 Nature 585, 1988.
Cech, "Ribozymes and Their Medical Implications" 260 JAMA 3030, 1988.
Jefferies et al., "A catalytic 13-mer ribozyme", 17 Nucleic Acid Research 1371, 1989.
Rossi et al., "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications and Problems", 8 AIDS Research and Human Retroviruses 183, 1992.
Hampel and Tritz, 28 Biochemistry 4929, 1989.
Hampel et al., 18 Nucleic Acids Research 299, 1990.
Perrotta and Been, 31 Biochemistry 16, 1992.
Guerrier-Takada et al., 35 Cell 849, 1983.
Tanaka et al, 23 Virus Res. 39, 1992.
Choo et al 88 Proc. Natl. Acad. Sci. USA 2451 1991.
Hampel et al., "RNA Catalyst for Cleaving Specific RNA Sequences", filed Sep. 20, 1989, which is a Continuation-in-Part of U.S. Serial No. 07/247,100 filed Sep. 20, 1988.
Weeerasinghe et al., 65 "Resistance to Human Immunodeficiency Virus Type 1 (HIV-1) Infection in Human CD4.sup.+ Lymphocyte-Derived Cell Lines Conferred by Using Retroviral Vectors Expressing an HIV-1 RNA-Specific Ribozyme", Journal of Virology 5531, 1991.
Mamone et al., "Design of Hammerhead Ribozymes Targeted to Sequences in HIV, HSV, and the RAT ANF GENE", Abstract of Keystone, CO (May 27, 1992).
Pavco et al., "Regulation of Self-Splicing Reactions by Antisense RNA", Abstract of Keystone, CO (May 27, 1992).
Tsukiyama-Kohara et a., 66 J. V. 1476, 1992.
Yoo et al. 191 Vir. 889, 1992.
Okamoto et al., 190 Vir. 894, 1990.
Martell et al., 13 J. Hepatol. Suppl. 2, 551, 1991.
Rossi et al., J. Cell Biochem., Suppl 14A D428, 1990.
Sarver et al., "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents" 247 Science 1222, 1990.

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