Process for preparing 2.beta.-substituted-methylpenicillin deriv

Details Process for preparing 2.beta.-substituted-methylpenicillin deriv Process for preparing 2.beta.-substituted-methylpenicillin deriv

1989-02-28

1990-02-06

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49900

Patent

active

048989398

ABSTRACT:
A process for preparing a 2.beta.-substituted-methylpenicillin compound of the formula ##STR1## wherein --N Y is an optionally substituted heterocyclic group containing 2 to 4 nitrogen atoms as the hetero atom in the ring structure, and R.sub.1 is a penicillin carboxyl protecting group, the process comprising reacting an azetidinonedisulfide compound of the formula ##STR2## wherein R.sub.1 is as defined above and R is a substituted or unsubstituted heterocyclic group with a nitrogen-containing heterocyclic compound of the formula ##STR3## wherein ##STR4## is as defined above in the presence of a metal compound.

REFERENCES:
patent: 4482565 (1984-11-01), Fogler et al.
patent: 4496484 (1985-01-01), Micetich et al.
patent: 4529592 (1985-07-01), Micetich et al.
patent: 4562073 (1985-12-01), Micetich et al.
patent: 4668514 (1987-05-01), Micetich
Synthesis 1986, 292 published in Apr. 1986 and authored by Micetich et al, Tetrahedron Letters, No. 38, pp. 3303-3306 (1975).

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