Substrate for the epidermal growth factor receptor kinase, antib

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

5303879, 53038824, 5303892, G01N 3353, C07K 1624

Patent

active

056100183

ABSTRACT:
A new substrate of epidermal growth factor receptor and other tyrosine kinase receptors denominated eps8, polynucleotide encoding eps8, antisense eps8 polynucleotide, antibodies to eps8, and assays for determining eps8.

REFERENCES:
I. Fazioli et al. J Biol Chem 267: 5155-5161 (1992).
Aaronson, S., "Growth Factors and Cancer" Science 254: 1146-1153 (Nov. 22, 1991).
Anderson, D., et al., "Binding of SH2 Domains of Phospholipase C.gamma.1, GAP and Src to Activated Growth Factor Receptors", Science 250: 979-981 (Nov. 16, 1990).
Broek, D., et al., "The S. cerevisiae CDC25 Gene Product Regulates the RAS/Adenylate Cyclase Pathway", Cell, 48: 789-799 (Mar. 13, 1987).
Cleveland, D., W., et al., "Peptide Mapping by Limited Proteolysis in Sodium Dodecyl Sulfate and Analysis by Gel Electrophoresis", J. Biol. Chem. 252(3): 1102-1106 (Feb. 10, 1977).
Coughlin, S., R., et al., "Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction", Science 243: 1191-1194 (Mar. 3, 1989).
Drubin, et al., "Homology of a yeast actin-binding protein to signal transduction proteins and myosin-1", Nature 343: 288-290 (Jan. 18, 1990).
Escobedo, J., A., et al., "A Phoshphatidylinositol-3 Kinase Binds to Platelet-Derived Growth Factor Receptors through a Specific Receptor Sequence Containing Phosphotyrosine", Mol. Cell. Biol. 11(2): 1125-1132 (Feb. 1991).
Escobedo, J., A., et al., "cDNA Cloning of a Novel 85kd Protein that has SH2 Domains and Regulates Binding of PI3-Kinase to the PDGF-.beta.Receptor", Cell 65: 75-82 (Apr. 5, 1991).
Fazioli, F. et al., "The erbB-2 Mitogenic Signaling pathway: Tyrosine Phosphorylation of Phospholipase C.gamma. and GTPase-Activating Protein Does Not Correlate with erbB-2 Mitogenic Potency", Mo. Cell. Biol. 11(4): 2040-2048 (Apr. 1991).
Fazioli, F., et al., "Identification and Biochemical Characterization of Novel Putative Substrates for the Epidermal Growth Factor Receptor Kinase", J. Biol. Chem. 267(8): 5155-5161 (Mar. 15, 1992).
Felgner, P., L., et al., "Gene therapeutics", Nature 349: 351-352 (Jan. 24, 1991).
Giard, D., J., et al., "In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors", J. Natl. Cancer Inst. 51(5): 1417-1423 (Nov. 1973).
Gomez-Marquez, J., et al., "Prothymosin .alpha. is a nuclear protein", FEBS Letters 226(2): 217-216 (Jan. 1988).
Gould, K., L., et al., "Platelet-Derived Growth Factor Induces Multisite Phosphorylation of pp60.sup.c-src and Increases its Protein Tyrosine Kinase Activity", Mol. Cell. Biol. 8(8): 3345-3356 (Aug. 1988).
Green, P., J., et al., "The Role of Antisense RNA in Gene Regulation", Ann. Rev. Biochem. 55: 569-597 (1986).
Higuchi, R., "Recombinant PCR" Chapter 22 in PCR Protocols: A Guide to Methods and Applications, pp. 171-183 (1990).
Hughes, D., A., et al., "Homologous sctivators of ras in fission and budding yeast", Nature 344: 355-357 (Mar. 22, 1990).
Jung, G., et al., "The heavy chain of Acanthamoeba myosin IB is a fusion of myosin-like and non-myosin-like sequences", Proc. Natl. Acad. Sci., USA 84: 6720-6724 (Oct. 1987).
Kaplan, D., R., et al., "PDGF .beta.-Receptor Stimulates Tyrosine Phosphorylation of GAP and Association of GAP with a Signaling Complex", Cell 61: 125-133 (Apr. 6, 1990).
Kazlauskas, A., et al., "Autophosphorylation of the PDGF Receptor in the Kinase Insert Region Regulates Interactions with Cell Proteins", Cell 58: 1121-1133 (Sep. 22, 1989).
Kazlauskas, A., et al., "Binding of GAP to Activated PDGF Receptors", Science 247: 1578-1581 (Mar. 30, 1990).
Kirkness, E., F., et al., "Isolation, Characterization, and Localization of Human Genomic DNA Encoding the .beta.1 Subunit of the GABA.sub.a Receptor (GABRB1)", Genomics 10: 985-995 (1991).
Kitamura, D., et al., "Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage", Nucleic Acids Res. 17(22): 9367-9379 (1989).
Koch, C., A. et al., "SH2 and SH3 Domains: Elements That Control Interactions of Cytoplasm Signaling Proteins" Science 252: 668-674 (May 3, 1991).
Kraus, M., H., et al., "[46] Detection and Isolation of Novel Protein-Tyrosine Kinase Genes Employing Reduced Stringency Hybridization", Methods in Enzymology 200: 546-557 (1991).
Kypta, R. M., et al., "Association between the PDGF Receptor and Cell" 62: 481-492 (1990).
Leto, et al., "Cloning of a 67 kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60.sup.c-src ", Science 248: 727-730 (May 11, 1990).
Margolis, et al., "EGF Induces Tyrosine Phosphorylation of Phospholipase C-II: A Potential Mechanism for EGF Receptor Signaling", Cell 57: 1101-1107 (Jun. 30, 1989).
Margolis, et al., "The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-.gamma.", The EMBO Journal 9(13): 4375-4380 (1990).
Matsuda, et al., "Binding of Transforming Protein p47.sup.gag-crk, to a Broad Range of Phosphotyrosine-Containing Proteins", Science 248: 1537-1539 (Jun. 22, 1990).
Mayer, et al., "Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity", Proc. Natl. Acad. Sci. USA 87: 2638-2642 (Apr. 1990).
Meisenhelder, et al., "Phospholipase c-.gamma. Is a Substrate for the PDGF and EGF Receptor Protein-Tyrosine Kinases In Vivo and In Vitro", Cell 57: 1109-1122 (Jun. 30, 1989).
Miki, et al., "Expression cDNA Cloning of the KGF Receptor by Creation of a Transforming Autocrine Loop", Science 251: 72-75 (Jan. 4, 1991).
Molloy, et al., "PDGF induction of tyrosine phosphorylation of GTPase activating protein", I Nature 342: 711-714 (Dec. 7, 1989).
Moran, et al., "Src homlogy region 2 domains direct protein-protein interactions in signal transduction", Proc. Natl. Acad. Sci., USA 87: 8622-8626 (Nov. 1990).
Morrison, D., K., et al., "Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-.gamma. with the PDGF Receptor Signaling Complex" Mol. Cell. Biol. 10(5): 2359-2366 (May 1990).
Morrison, D., K., et al., "Direct Activation of the Serine/Threonine Kinase Activity of Raf-1 through Tyrosine Phosphorylation by the PDGF .beta.-Receptor", Cell, 56: 649-657 (Aug. 25, 1989).
Morrison, D., K., et al., "Signal transduction from membrane to cytoplasm: Growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity", Proc. Natl. Sci, USA 85:8855-8859 (Dec. 1988).
Otsu, M., et al., "Characterization of Two 85 kd Proteins That Associate with Receptor Tyrosine Kinases, Middle-T/pp60.sup.c-src Complexes, and PI3-Kinase", Cell 65:91-104 (Apr. 5, 1991).
Rossi, J., J., et al., "The Potential Use of Catalytic RNAs in Therapy of HIV Infection and Other Diseases", Pharmac. Ther. 50: 245-254 (1991).
Ruderman, N., B., et al., "Activation of phosphatidylinositol 3-kinase by insulin", Proc. Natl. Acad. Sci., USA 87: 1411-1415 (Feb. 1990).
Segatto, O., et. al., "The Juxtamembrane Regions of the Epidermal Growth Factor Receptor and gp185.sup.erbB-2 Determine the Specificity of Signal Transduction", Mol. Cell. Biol. 11(6): 3191-3202 (Jun. 1991).
Skolnik, E., Y., et al., "Cloning of PI3 Kinase-Associated p85 Utilizing a Novel Method for Expression/Cloning of Target Proteins for Receptor Tyrosine Kinases", Cell 65: 83-90 (Apr. 5, 1991).
Trueheart, J., et al., "Two Genes Required for Cell Fusion during Yeast Conjugation: Evidence for a Pheromone-Induced Surface Protein". Mol. Cell. Biol. 7(7): 2316-2328 (Jul. 1987).
Ullrich, A., et al., "Signal Transduction by Receptors with Tryosine Kinase Activity", Cell 61: 203-212 (Apr. 20, 1990).
Varticovski, L., et al., "The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase", Nature 342: 699-702 (Dec. 7, 1989).
Wahl, M., I., et al., "Platelet-Derived Growth Factor Induces Rapid and Sustained Tyrosine Phosphorylation C-.gamma. in Quiescent BALB/c 3T3 Cells", Mol. Cell. Biol. 9(7): 2634-2943 (Jul. 1989).
Wasenius, V., et al., "Primary Structure of the Brain .alpha.-Spectrin", J. Cell. Biol. 108:79-93 (Jan. 1989).
Wolff, et al., "Direct Gene Transfer in Mouse Muscle in Vivo" Sci

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substrate for the epidermal growth factor receptor kinase, antib does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substrate for the epidermal growth factor receptor kinase, antib, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substrate for the epidermal growth factor receptor kinase, antib will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-442446

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.