Method for diagnosing a disorder by determining expression of ga

Details Method for diagnosing a disorder by determining expression of ga Method for diagnosing a disorder by determining expression of ga

1994-05-27

1997-03-11

Hendricks, Keith D.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 4352523, 43525233, 4353201, 435325, 435365, 435358, 435362, 536 235, C12Q 168, C12N 500, C12N 120, C07H 1900

Patent

active

056100132

ABSTRACT:
A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.

REFERENCES:
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Wolfel et al., "Lysis of Human Melanoma Cells By Autologous-Cytolytic T Cell Clones", J. Exp. Med. 170: 797-810 (Sep. 1989).
Van Den Eynde et al., "Presence On a Human Melanoma of Multiple-Antigens Recognized by Autologous CTL", Int. J. Cancer 44: 634-640 (1989).
Van der Bruggen, et al., "A Gene Encoding An Antigen Recognized-By Cytolytic T Lymphocytes on a Human Melanoma", Science 254: 1643-1647 (Dec. 1991).
Brasseur et al., "Human Gene MAGE-1, which codes for a tumor-rejection antigen, is expressed by some breast tumors", Int. J. Cancer 52: 839-841 (1992).
Traversari et al., "Transfection and expression of a gene-coding for a human melanoma antigen recognized by autologous cytolytic T lymphocytes", Immunogenetics 35: 145-152 (1992).
Traversari et al., "A Nonapeptide Encoded by Human Gene MAGE-1-Is Recognized on HLA-A1 By Cytolytic T Lymphocytes Directed Against Tumor Antigen MZ2-E", J. Exp. Med. 176: 1453-1457 (Nov. 1992).

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