Methods for the treatment of hypertension

Details Methods for the treatment of hypertension Methods for the treatment of hypertension

1989-03-27

1990-02-06

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514212, 5142275, 5142278, 5142315, 5142358, 5142362, 5142365, 5142368, 514241, 514247, 514252, 514255, 514256, 514317, 514318, 514326, 514331, 514343, 514344, 514345, 514346, 514351, 514355, 514357, 514359, 514362, 514363, 514365, 514374, 514396, 514397, 514406, 514408, 514422, 514427, 514428, 514438, 514445, 514452, 514464, 514471, 514524, 514546, 514552, 514625, 514629, 514630, 5143338, 514321, 564374, 564381, 564382, A61K 31135, A61K 3140, A61K 31445, A61K 31535

Patent

active

048988898

ABSTRACT:
Acetylene compounds of the formula (I): ##STR1## wherein Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The compounds possess antihypertensive and anti-anginal properties and may be used in the treatment of humans. Methods for the preparation and use of such acetylene compounds are also disclosed.

REFERENCES:
patent: 3719712 (1973-03-01), Remy
patent: 4661635 (1987-04-01), Carson
patent: 4725602 (1988-02-01), Carson
Remy et al., J. Med. Chem., vol. 18, pp. 142-148 (1975).

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