Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-04-15
1990-02-06
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514323, 514445, 514419, 544132, 544143, 544371, 544373, 546201, 546199, 548253, 548494, 548503, A61K 31535, A61K 31405, C07D21106, C07D20914
Patent
active
048988634
ABSTRACT:
This invention provides a series of novel heterocyclic carboxamides of formula I in which the group --Y--Z< is selected from --C(Ra).dbd.C<, --N.dbd.C<, and --CH(Ra)--CH< and the other radicals have the meanings defined in the following specification.
The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseasxes, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
REFERENCES:
patent: 3271416 (1966-09-01), Shen et al.
patent: 3415841 (1968-12-01), Nordmann et al.
patent: 3470298 (1969-09-01), Palazzo
patent: 4277489 (1981-07-01), Vandoni
patent: 4499299 (1985-02-01), Bernstein et al.
Hannig, e., et al., Pharmazie (1974), 29, H. 10-11, 685-686.
Marx, J. L., Science (1982), 215, 1380-1382.
Krell, R. D., J. Pharmacol. Exp. Ther. (1979), 211, 436-433.
Fleisch, J. H, et al., J. Pharmacol Exp. Ther. (1985), 233, 148-157.
Cook, J. A., et al., J. Pharmacol. Exp. Ther. (1985), 235, 470-474.
Denzlinger, C., et al., Science (1985), 230, 330-332.
Brown Frederick J.
Yee Ying K.
Brust Joseph Paul
Howard Mary Sue
ICI Americas Inc.
Jackson Thomas E.
Miano Rosemary M.
LandOfFree
Heterocyclic carboxamides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heterocyclic carboxamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic carboxamides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-441960