Aromatic steroid 5-.alpha.-reductase inhibitors

Details Aromatic steroid 5-.alpha.-reductase inhibitors Aromatic steroid 5-.alpha.-reductase inhibitors

1989-07-14

1990-09-04

Shah, Mukund J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Enzyme inactivation by chemical treatment

552502, 552548, 552552, 552541, 552546, 552613, 552610, 552554, 552553, 552626, 552611, 552614, 552646, 552627, 552651, 552522, 552532, 552558, 552515, 552539, 540110, 540 98, 540 28, 540 96, 540108, 514176, 514177, 2603971, 2603972, 558 57, A61K 3156, C07J 4100

Patent

active

049544462

ABSTRACT:
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.

REFERENCES:
patent: 4191759 (1980-03-01), Johnston et al.
patent: 4317817 (1982-03-01), Blohm et al.
patent: 4361578 (1982-11-01), Alia et al.
patent: 4377584 (1983-03-01), Rasmusson et al.
Cacchi, et al., Tetrahedron Letters, 27(33), 1986, pp. 3931-3934.
Liang, et al., Steroid Biochemistry, vol. 19(1), 1983, pp. 385-390.
Petrow, et al., Steroids 38(2), 1981, pp. 121-140.

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