Photoprotection compositions comprising tocopherol sorbate and a

Details Photoprotection compositions comprising tocopherol sorbate and a Photoprotection compositions comprising tocopherol sorbate and a

1989-06-26

1990-09-04

Ore, Dale R.

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

252106, 252107, 252305, 252312, 424DIG5, 424 47, 424 60, 424 63, 424 64, 424 70, 514458, 514474, 514559, 514563, 514575, 514846, 514847, 514937, 514944, 514945, A61K 7027, A61K 7106, A61K 742, A61K 912

Patent

active

049543326

ABSTRACT:
Disclosed are pharmaceutical compositions comprising tocopherol sorbate and an anti-inflammatory agent which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combinations of tocopherol sorbate, an anti-inflammatory agent, and a sunscreen are also disclosed.
Also disclosed is a method for using these compositions topically to prevent damage to skin caused by acute or chronic UV exposure.

REFERENCES:
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Law et al, "The Effect of Systematically and Topically Applied Drugs on Ultraviolet-Induced Erythema in the Rat", 59 Br. J. Pharm. 591 (1977).
Kaidbey et al, "The Influence of Corticosteroids and Topical Indomethacin on Sunburn Erythema", 66 The Journal of Investigative Dermatology 153 (1976).
Gruber et al, "Delay of Erythema of Human Skin by Anti-inflammatory Drugs After Ultraviolet Irradiation", 13(1) Clinical Pharmacology and Therapeutics 109 (1971).
U.S. Ser. No. 112,577, filed 10/22/87, Chatterjee et al, now U.S. Pat. No. 4,847,071, 7/11/89.

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