Farnesylated tetrahydro-naphthalenols as hypolipidemic agents

Details Farnesylated tetrahydro-naphthalenols as hypolipidemic agents Farnesylated tetrahydro-naphthalenols as hypolipidemic agents

1992-12-23

1994-03-22

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

546322, 560138, 514356, A61K 31215, C07C 69017

Patent

active

052965082

ABSTRACT:
The invention relates to novel farnesylated tetrahydro-naphthalenols, that inhibit HMGR activity which results in a decrease in serum total cholesterol, a decrease in LDL cholesterol levels, and inhibition of LDL oxidation. The farnesylated tetrahydro-naphthalenols of the present invention are thus useful for cholesterol/lipid lowering in cases of hypercholesterolemia, hyperlipidemia, and atherosclerosis.

REFERENCES:
patent: 4680310 (1987-07-01), Hengartner et al.

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