Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-12-08
1994-03-22
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142338, 514321, 514253, 548211, 544135, 544337, 546 22, A61K 31425, C07D27506
Patent
active
052964965
ABSTRACT:
4-R.sub.1 -R.sub.2 -R.sub.3 -2-Saccharinylmethyl and 4,7-C-4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates of formulas I and IIA respectively herein, useful in the treatment of degenerative diseases, and compositions containing them, methods for using them to treat degenerative diseases, and processes for their preparation by reaction of the corresponding 2-halomethylsaccharins with a phosphate, phosphonate or phosphinic acid of formula III herein in the presence of an acid-acceptor.
REFERENCES:
patent: 3002884 (1961-10-01), Lo
patent: 3314960 (1967-04-01), Freed et al.
patent: 4195023 (1980-03-01), Mulvey et al.
patent: 4263393 (1981-04-01), Chen
patent: 4276298 (1981-06-01), Jones et al.
patent: 4350752 (1982-09-01), Reczek et al.
patent: 4363865 (1982-12-01), Reczek et al.
patent: 4410618 (1983-10-01), Vanmeter et al.
patent: 4547371 (1985-10-01), Doherty et al.
patent: 4623645 (1986-11-01), Doherty et al.
patent: 4659855 (1987-04-01), Powers
Chemical Abstracts 81, 22249n (1974), Chiyomaru et al., Bactericidal . . . Use.
Sunkel et al., J. Med. Chem. 31, 1886-1890 (1988), Synthesis, Platelet . . . 1,4-Dihydropyridines.
Zimmerman et al., J. Biol. Chem. 255(20), 9848-9851 (1980).
Teshima et al., J. Biol. Chem., 257(9), 5085-5091 (1982), A New Class . . . Inhibitors.
Cha, Biochem. Pharmacol., 24, 2177-2185 (1975), Tight-Bindind Inhibitors-I.
Powers et al., Biochem., 24, 2048-2058 (1985), Mammalian . . . Inhibitors.
Svoboda et al., Coll. Czech. Chem. Commun., 51, 1133-1139 (1986), The Synthesis . . . 1,1-Dioxides.
Court John J.
Desai Ranjit C.
Hlasta Dennis J.
Hohenschutz Liza D.
Lee Mary C.
McKane Joseph K.
Sterling Winthrop Inc.
LandOfFree
2-saccharinylmethyl phosphates, phosphonates and phosphinates us does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2-saccharinylmethyl phosphates, phosphonates and phosphinates us, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-saccharinylmethyl phosphates, phosphonates and phosphinates us will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-437349