Pyridazinone derivatives, and pharmaceutical compositions contai

Details Pyridazinone derivatives, and pharmaceutical compositions contai Pyridazinone derivatives, and pharmaceutical compositions contai

1987-08-03

1989-07-11

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544180, 544295, 544194, 544219, 544237, 544238, 514241, 514245, 514248, 514249, 514252, 514253, 514254, A61K 3150, A61K 31505, A61K 3153, C07D40104

Patent

active

048472514

ABSTRACT:
The present invention provides pyridazinone derivatives of the general formula: ##STR1## wherein Het is a mono- or bicyclic heterocycle with one or two nitrogen atoms, B-C is a --CHR.sub.1 --CH.sub.2 --, --CR.sub.1 .dbd.CH--, --CHR.sub.1 --O--, --O--CHR.sub.1 --, --CHR.sub.1 --NH-- or --NH--CHR.sub.1 -- group, R.sub.1 being a hydrogen atom or an alkyl radical, and A is an amiono, alkylcarbonylamino, aminocarbonylamino, aminothiocarbonylamino, alkylaminothiocarbonylamino, alkylamionocarbonylamino, N'-cyanoguanidino or N'-cyano-N"-alkylguanidino group, a substituted phenyl ring or heterocycle attached via a nitrogen or sulphur atom, or a mono- or bicyclic substituted heterocycle with 1 to 3 nitrogen atoms, one ring nitrogen atom being directly attached to Het; as well as the physiologically acceptable salts thereof.
The present invention also provides processes for the preparation of these pyridazinone drivatives and pharmaceutical compositions containing them for the treatment of heart and circulatory diseases.

REFERENCES:
patent: 4643998 (1987-02-01), Hilboll et al.
patent: 4667033 (1987-05-01), Hilboll et al.
patent: 4783463 (1988-11-01), Kuhla et al.
Hauel et al., Chemical Abstracts Entry 106:18589r (1987) of German Offen 3,511,110 published Oct. 2, 1968.
International Application Published Under the Patent Cooperation Treaty WO 87/02587, International Publication Date: 7 May 1987.

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