Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethy

Details Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethy Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethy

1990-05-01

1991-12-24

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544366, 544370, A61K 31495, C07D40514

Patent

active

050753096

ABSTRACT:
4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]m ethoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones, their pharmaceutically acceptable acid addition salts and stereoisomeric forms having improved antifungal properties, compositions containing the same, and methods of inhibiting and/or preventing the growth or the development of fungi, or of destroying fungi, in warm-blooded animals suffering from diseases caused by these fungi.

REFERENCES:
patent: 4267179 (1981-05-01), Heeres et al.
patent: 4735942 (1988-04-01), Heeres et al.
patent: 4916134 (1990-04-01), Heeres et al.
Chem. Abstract, vol. 106, No. 67318k (1987).
Heeres et al., J. Med. Chem., vol. 27, No. 7, (1984), pp. 894-900.

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