Method for treating urinary obstruction

Details Method for treating urinary obstruction Method for treating urinary obstruction

1990-02-15

1991-12-24

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 3150, A61K 31495

Patent

active

050753088

ABSTRACT:
A method for treating urinary obstruction by administering a 2-(4-phenyl-1-piperazinylalkyl)aminopyrimidine derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.3 may be the same or different and independently represent hydrogen, halogen, an amino group, a hydroxyl group, a straight or branched chain lower alkyl group, a straight or branched chain lower alkoxy group, or a straight or branched chain hydroxy-lower alkyl group, R.sub.2 represents hydrogen, halogen, a carboxyl group, a straight or branched chain lower alkyl group, a straight or branched chain lower alkylcarbonyl group, or a straight or branched chain lower alkyloxycarbonyl group, R.sub.4 and R.sub.5 may be the same or different and independently represent hydrogen, halogen, a straight or branched chain lower alkyl group, or a straight or branched chain lower alkoxy group, and n represents an integer of 2 to 6 or a pharmaceutically acceptable acid addition salt thereof to a mammal including a human afflicted with urinary obstruction. The aminopyrimidine derivatives have a selective activity on the .alpha..sub.1 -adrenoceptors in the urinary tracts.

REFERENCES:
Iyaku Journal, vol. 24, No. 12, p. 2661 (1988).
Nihon Hinyoki Gakkai-shi, vol. 76, 325-327 (1985).
Iyaku to Yakugaku, vol. 19, 411.varies.429 (1988).

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