Subtilisin as an oral thrombolytic agent

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

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435222, A61K 37547

Patent

active

052962237

ABSTRACT:
There are provided thrombolytic agents suited for oral administration. The agent comprises a proteolytic enzyme of subtilisin family, such as subtilisin BPN', subtilisin Carsberg, subtilisin amylosacchariticus, etc., produced by microorganisms belonging to genus Bacillus, such as Bacillus subtilis, Bacillus licheniformis, Bacillus amyloliquefaciens, etc. and, even when administered orally, exhibits thrombolytic activity.

REFERENCES:
Rudenskaya et al., BA85:89212, 1987.
Magda et al., Acta Phys. Acad Sci Hung 44 (3/4) 1975.

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