Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1992-10-13
1994-03-22
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
435222, A61K 37547
Patent
active
052962237
ABSTRACT:
There are provided thrombolytic agents suited for oral administration. The agent comprises a proteolytic enzyme of subtilisin family, such as subtilisin BPN', subtilisin Carsberg, subtilisin amylosacchariticus, etc., produced by microorganisms belonging to genus Bacillus, such as Bacillus subtilis, Bacillus licheniformis, Bacillus amyloliquefaciens, etc. and, even when administered orally, exhibits thrombolytic activity.
REFERENCES:
Rudenskaya et al., BA85:89212, 1987.
Magda et al., Acta Phys. Acad Sci Hung 44 (3/4) 1975.
Hiratani Hajime
Kato Kazuo
Nakanishi Koichiro
JCR Pharmaceuticals Co. Ltd.
Robinson Douglas W.
Witz Jean C.
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