Genetic markers of schizophrenia

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091100, C536S023100, C536S024300, C536S024330

Reexamination Certificate

active

08067160

ABSTRACT:
The invention includes method of determining if a subject has a genetic predisposition to clinically diagnosed schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD).

REFERENCES:
patent: 2006/0177851 (2006-08-01), Brennan et al.
Pearson et al., How to Interpret a Genome-wide Association Study. JAMA, 299, 1335-1344, 2008.
Stefansson et al., Common variants conferring risk of schizophrenia. Nature, 460, 744-747, 2009.
Shi et al., Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature, 460, 753-757, 2009.
Hennah et al., “Hapltype analysis and identification of genes for complex trait: examples from schizophrenia,”Annals of Medicine, 36:322-331 (2004).
Riley et al., “Molecular genetics studies of schizophrenia,”European Journal of Human Genetics, 14:669-680 (2006).
Hegele, R.A., “SNP judgment and freedom of association,”Arteriocler. Thromb. Vasc. Biol., 22:1058-1061 (2002).
Baker et al., “COMT Va1108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome,”Biol. Psychiatry, 58(1):23-31 (2005).
Brennan et al., “Polymorphic markers for the arylsulfatase A gene reveal a greatly expanded meiotic map for the human 22q telomeric region ,”Genomics, 63:430-432 (2000).
Cadenhead, K.S., “Vulnerability markers in the schizophrenia spectrum: implications for phenomenology, genetics, and the identification of the schizophrenia prodrome,”Psychiatric Clinics of North America, 25(4):837-853 (2002).
Callicott et al., “Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia,”Proc. Natl. Acad. Sci USA, 102(24):8627-8632 (2005).
Cannon et al., “Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory,”Arch. Gen. Psychiatry, 62(11):1205-1213 (2005).
Durand et al., “Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders,”Nat. Genet., 39(1):25-27 (2007) [Epub Dec. 17, 2006].
Gornick et al., “Dysbindin (DTNBP1, 6p22.3) is Associated with Childhood-Onset Psychosis and Endophenotypes Measured by the Premorbid Adjustment Scale (PAS),”J. Autism Dev. Disord., 35(6):831-838 (2005).
Gothelf et al., “COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome,”Nat. Neurosci., 8(11):1500-1502 (2005).
Gottesman and Gould, “The endophenotype concept in psychiatry: etymology and strategic intentions,”Am. J. Psychiatry, 160(4):636-645 (2003).
Hallmayer et al., “Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit,”Am. J. Hum. Genet., 77(3):468-476 (2005).
Harrison and Owen, “Genes for schizophrenia? Recent findings and their pathophysiological implications,”Lancet, 361(9355):417-419 (2003).
Heinrichs, R.W., “Meta-analysis and the science of schizophrenia: variant evidence or evidence of variants?”Neuroscience&Biobehavioral Reviews, 28(4):379-394 (2004).
Kaufmann et al., “NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees,”Am. J. Med. Genet., 81:282-289 (1998).
Kavenoff et al., “One the nature of chromosome-sized DNA molecules,”Cold Spring Harbor Symposia on Quantitative Biology, 38:1-8 (1974).
Kendler et al., “Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study,”Am. J. Psychiatry, 152(5):749-754 (1995).
Mattila et al., “Fidelity of DNA synthesis by theThermococcus litoralisDNA polymerase—an extremely heat stable enzyme with proofreading activity,”Nucleic Acids Res., 19:4967-4973 (1991).
Saiki et al., “Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes,”Nature, 324:163-166 (1986).
Sheffield et al., “Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes,”Proc. Natl. Acad. Sci. USA, 86:232-236 (1989).

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