Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2010-05-20
2011-12-27
Allen, Marianne P (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
08084426
ABSTRACT:
FGF18 is known to stimulate the proliferation of chondrocytes, bone, and nervous tissue, resulting in repair of diseased tissue. When an IL-1 antagonist is administered in addition to FGF18, the effects on the IL-1 mediated disease and also, the effect on cartilage, bone, and nervous cell proliferation, are found to be greater than administration of FGF18 or the IL-1 antagonist alone. The present invention encompasses a pharmaceutical composition that combines FGF18 with IL-1 antagonist and methods of treating IL-1 mediated disease using this pharmaceutical composition.
REFERENCES:
patent: 6352971 (2002-03-01), Deisher et al.
patent: 6599873 (2003-07-01), Sommer et al.
patent: 6733753 (2004-05-01), Boone et al.
patent: 7067144 (2006-06-01), Demopulos et al.
patent: 7745138 (2010-06-01), Whitehead
patent: 7749965 (2010-07-01), Moore et al.
patent: 2003/0199443 (2003-10-01), Deisher et al.
patent: 2004/0136970 (2004-07-01), Ellsworth et al.
patent: 2006/0009389 (2006-01-01), Moore et al.
patent: 2008/0194472 (2008-08-01), Whitsett
patent: WO 0139788 (2001-06-01), None
patent: WO 2004/022718 (2004-03-01), None
patent: WO 2004/032848 (2004-04-01), None
patent: WO 2004/032849 (2004-04-01), None
patent: WO 2004/047857 (2004-06-01), None
patent: WO 2006/014444 (2006-02-01), None
Ellsworth J L et al., “Fibroblast Growth Factor-18 (FGF 18) Reduces Infarct Volume and Behavioral defecit After Occlusion of the Middle Cerebral Artery in Rats”, BIOSIS, 2001, vol. 27, No. 2, p. 2026.
Ellsworth et al., “Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors”, Osteoarthritis and Cartilage/OARSI, Osteoarthritis Research Society, Apr. 2002, vol. 10, No. 4, pp. 308-320.
Hu et al., “FGF-18, a novel member of the fibrblast growth factor family, stimulates hepatic and intestinal proliferation”, Mollecular and Cellular Biology, Oct. 1998, vol. 18, No. 10, pp. 6063-6074.
Ellsworth Jeff L.
Moore Emma E.
Allen Marianne P
Woodcock & Washburn LLP
ZymoGenetics Inc.
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