Small volume in vitro sensor and methods of making

Details Small volume in vitro sensor and methods of making Small volume in vitro sensor and methods of making

2009-09-29

2011-12-27

Noguerola, Alex (Department: 1759)

Electrolysis: processes, compositions used therein, and methods

Electrolytic analysis or testing

Of biological material

C205S777500, C204S403020, C204S403040

Reexamination Certificate

active

08083929

ABSTRACT:
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

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