Substituted dihydropyrazolones and their use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S228800, C514S252190, C514S256000, C540S544000, C544S063000, C544S295000, C544S328000

Reexamination Certificate

active

08067407

ABSTRACT:
The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and haematological diseases and kidney diseases, and for promoting wound healing.

REFERENCES:
patent: 4075003 (1978-02-01), Beck et al.
patent: 4118574 (1978-10-01), Beck et al.
patent: 4663327 (1987-05-01), Sasse et al.
patent: 4698344 (1987-10-01), Sasse et al.
patent: 4806540 (1989-02-01), Sasse et al.
patent: 2003/0083351 (2003-05-01), Almstead et al.
patent: 2006/0067927 (2006-03-01), Chandrasekaran et al.
patent: 2006/0160826 (2006-07-01), Ghanbari et al.
patent: 200029165 (2000-11-01), None
patent: 2364908 (2000-09-01), None
patent: 2608099 (2006-11-01), None
patent: 2667392 (2008-05-01), None
patent: 2651008 (1977-06-01), None
patent: 165448 (1985-12-01), None
patent: 183159 (1986-06-01), None
patent: 212281 (1987-03-01), None
patent: WO-96/12706 (1996-05-01), None
patent: WO-00/51989 (2000-09-01), None
patent: 0292573 (2002-11-01), None
patent: WO-03/051833 (2003-06-01), None
patent: WO-03/074550 (2003-09-01), None
patent: 2004052284 (2004-06-01), None
patent: 2004087066 (2004-10-01), None
patent: WO-2004/089303 (2004-10-01), None
patent: 2005030121 (2005-04-01), None
patent: WO-2006/101903 (2006-09-01), None
patent: 2006114213 (2006-11-01), None
patent: WO-2006/114213 (2006-11-01), None
patent: WO-2007/008541 (2007-01-01), None
patent: 2008049538 (2008-05-01), None
patent: 2008067871 (2008-06-01), None
patent: 2008067874 (2008-06-01), None
patent: WO-2008/067871 (2008-06-01), None
Vippagunta et al., Crystalline Solids, Advanced Drug Delivery Reviews, 48, pp. 3-26, 2001.
West, Solid Solutions, Chapter 10, pp. 358 and 365, 1988.
Ulrich, Crystallization: 4. Crystal Characteristics, Kirk-Othmer Encyclopedia of Chemical Technology, Aug. 2002.
G. Eder: “Allgemeine Pathologie und Pathologische Anatomie,” Aufl, Springer Verlag, Berlin, vol. 33, 1990.
R. F. Schmidt et al.: “Physiologie des Menschen,” Aufl, Springer Verlag, Berlin, vol. 27, 1997.
G. Löffler et al: “Biochemie und Pathobiochemie,” Aufl, Springer Verlag, Berlin, vol. 7, 2003, pp. 1-22.
M. Simons et al.: “Therapeutic Angiogenesis in Cardiovascular Disease,” Nat. Rev. Drug. Discov., vol. 2, No. 11, 2003, pp. 863-871.
K-U. Eckardt: “The Potential of Erythropoietin and Related Strategies to Stimulate Erythropoiesis,” Current Opinion in Investigational Drugs, vol. 2, No. 8, 2001, pp. 1081-1085.
J. S. Berns: “Should the Target Hemoglobin for Patients with Chronic Kidney Disease Treated with Erythropoietic Replacement Therapy be Changed?” Seminars in Dialysis, vol. 18, No. 1, Jan.-Feb. 2005, pp. 22-29.
K. Caiola et al.: “Use of Erythropoietin in Heart Failure Management,” The Annals of Pharmacotherapy, vol. 38, Dec. 2004, pp. 2145-2149.
S. D. Katz: “Mechanisms and Treatment of Anemia in Chronic Heart Failure,” Cong. Heart Failure, vol. 10, 2004, pp. 243-247.
G. L. Semenza: “Hypoxia-Inducible Factor 1: Oxygen Homeostasis and Disease Pathophysiology,” Trends in Molecular Medicine, vol. 7, No. 8, Aug. 2001, pp. 345-350.
R. H. Wenger et al.: “Oxygen(es) and the Hypoxia-Inducible Factor-1,” Biol. Chem., vol. 378, Jul. 1997, pp. 609-616.
A. C. R. Epstein et al.: “C. elegansEGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation,” Cell, vol. 107, Oct. 5, 2001, pp. 43-54.
R. K. Bruick et al.: “A Conserved Family of Prolyl-4-Hydroxylases that Modify HIF,” Science 294, Nov. 9, 2001, pp. 1337-1340.
M. Ivan et al.: “Biochemical Purification and Pharmacological Inhibition of a Mammalian Prolyl Hydroxylase Acting on Hypoxia-Inducible Factor,” Proc. Natl. Acad. Sci., vol. 99, No. 21, Oct. 15, 2002, pp. 13459-13464.
L. Aravind et al.: “The DNA-Repair Protein AlkB, EGL-9, and Leprecan Define New Families of 2-Oxoglutarate- and Iron-Dependent Dixygenases,” Genome Biology, vol. 2, No. 3, Feb. 19, 2001, pp. 1-8.
C. J. Schofield et al.: “Oxygen Sensing by HIF Hydroxylases,” Nature Reviews Molecular Cell Biology, vol. 5, May 2004, pp. 343-354.
J. Büchi et al.: “Synthese and Pharmakologische Eigenschaften Einiger Pyridyl-Pyrazol-5-one,” Helv. Chim. Acta, vol. 49, No. 1, 1966, pp. 272-280.
B. Djerrari et al.: “3-Methyl-1-(Pyridin-2-yl)-4-(1-Pyridin-2-yl-3-Methyl-1H-Pyrazol-5-yl)-2H-3-Pyrazolin-5(1HI)-one,” Acta Crystallographica Section E, Structure Reports Online, E57, No. 11, 2001, o1126-o1127.
S. P. Singh et al.: “Reaction of 1-[5-Hydroxy-3-Methyl-1-(2-Thiazolyl)-4-Pyrazolyl]-1,3-Butanediones with Phenyl and Heterocyclic Hydrazines: a Convenient Synthesis of 4,5-Bipyrazoles,” Indian Journal of Heterocyclic Chemistry, vol. 3, Jul.-Sep. 1993, pp. 5-8.
J. Elguero et al.: “A 1H and 13C NMR Study of the Structure and Tautomerism of 4-Pyrazolylpyrazolinones,” J. Heterocyclic Chem., vol. 37, No. 4, May-Jun. 1990, pp. 865-870.
H. Barth et al.: “Konstitution and Synthese des Muscafavins,” Liebigs Ann. Chem., 1981, pp. 2164-2179.
R.A. Evans et al.—Trifluromethyl-substituted Dehydrodizepines and Cyanopyrroles form Azido-ffetrazolo-pyridines, J Chem. Commun., vol. 15, 1992, pp. 1062-1064.
F. Oehme et al.: “A Nonradioactive 96-well Plate Assay for the Detection of Hypozia-Inducible Factor Prolyl Hydroxylase Activity,” Analytical Biochemistry, vol. 330, 2004, pp. 74-80.
F. Oehme et al.: “Overexpression of Ph-4, a Novel Putative Proline 4-Hydroxylase, Modulates Activity of Hypoxia-Inducible Transcription Factors,” Biochemical and Biophysical Research Communications, vol. 296, 2002, pp. 343-349.
C. A. Heid et al.: “Real Time Quantitative PCR,” Genome Research, vol. 6, No. 10, 1996, pp. 986-994.
N. Yokoyama et al.: “Synthesis and Structure-Activity Relationships of Oxamic Acid and Acetic Acid Derivatives Related to L-Thyronine,” J. Med. Chem. vol. 38, 1995, pp. 695-707.
N. Sperber et al.: “Parasympathetic Blocking Agents, III. N-Alkylpiperidinecarboxylic Esters,” J. Am. Chem. Soc. vol. 81, 1959, pp. 704-709.
M. A. Meziane et al.: “A New Route to 1-Oxo-1,2-Dihydropyrimido[1,6-a]Benzimidazole-4-Carboxylates from Ethyl 2- (Benzimidazol-2-yl)-3-(Dimethylamino)Acrylate Using Solvent-Free Conditions,” Synthesis, Jul. 1996, pp. 967-969.
U.S. Appl. No. 11/919,478, the US National Stage of International Application No. PCT/EP20061003488 filed on Apr. 15, 2006.
International Search Report for International Application No. PCT/EP2006/003488, published with the International Application as WO2006/114213 on Nov. 2, 2006.
U.S. Appl. No. 12/447,192, the US National Stage of International App. No. PCT/EP/2007/008977, filed on Oct. 17, 2007.
International Search Report for International App No. PCT/EP/2007/008977, published with the International Application as WO2008/067871 on May 2, 2008.
U.S. Appl. No. 12/447,201, the US National Stage of International App No. PCT/EP/20071008877, filed on Oct. 12, 2007.
International Search Report for International App No. PCT/EP/2007/008877, published with the International Application as WO2008/049538 on Jun. 12, 2008.
U.S. Appl. No. 12/447,207, the US National Stage of International App No. PCT/EP/20071008951, filed on Oct. 16, 2007.
International Search Report for International App No. PCT/EP/2007/008951, published with the International Application as WO2008/067874 on Jun. 12, 2008.
An English translation of WO2006/114213 was published as US Application Publication No. 20100035906 on Feb. 11, 2010. (U.S. Appl. No. 11/919,478).
An English translation of WO2008/067871 was published as US Application Publication No. 20100305085 on Dec. 2, 2010 (U.S. Appl. No. 12/447,192).
An English translation of WO2008/049538 was published

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substituted dihydropyrazolones and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted dihydropyrazolones and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted dihydropyrazolones and their use will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4309582

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.