Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2007-08-24
2011-11-29
O'Dell, David K. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C544S239000, C514S247000, C514S252010
Reexamination Certificate
active
08067590
ABSTRACT:
The present invention relates to compounds of general formula Iwherein the groups and radicals B, k, L, U, V, W, X, Y, Z, R1, R2, have the meanings given in claim1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
REFERENCES:
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patent: 2 618 112 (2007-02-01), None
patent: 2005/085200 (2005-09-01), None
patent: 2007/018248 (2007-02-01), None
Guo et. al. “Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis” Bioorganic & Medicinal Chemistry Letters 2005, 15, 3696-3700.
International Search Report and Written Opinion for PCT/EP2007/058601 mailed Feb. 6, 2008.
Hazel J. Dyke, et al; Recent Developments in the Discovery of MCH-1R Antagonists for the Treatment of Obesity—an Update; Expert Opinion on Therapeutic Patents (2005) vol. 15, No. 10 pp. 1303-1313.
Heckel Armin
Kley Joerg
Lehmann-Lintz Thorsten
Lotz Ralf
Mueller Stephan Georg
Boehringer Ingelheim International GmbH
Devlin Mary-Ellen M.
Morris Michael P.
O'Dell David K.
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