Cyclopropyl compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S185000

Reexamination Certificate

active

08063079

ABSTRACT:
A compound of the formula:and pharmaceutical compositions for the treatment of diabetes.

REFERENCES:
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patent: 2007/051847 (2007-05-01), None
patent: 2009/133687 (2009-11-01), None
Zhang, et al., “Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase,” Bioorganic & Medicinal Chemistry, vol. 17, pp. 7301-7312 (2009).
Wei, et al., “Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells,” Diabetologia, vol. 52, pp. 2142-2150 (2009).
Efanov, et al., “A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function,” Endocrinology, vol. 146, No. 9, pp. 3696-3701 (2005).
Heuser, et al., “Synthesis of novel cyclopropylic sulfones and sulfonamides acting as glucokinase activators,” Tetrahedron Letters, vol. 47, pp. 2675-2678 (2006).

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