Method for determining crystallization parameters and...

Details Method for determining crystallization parameters and... Method for determining crystallization parameters and...

2007-11-13

2011-12-20

Warden, Jill (Department: 1773)

Chemistry: analytical and immunological testing

Process or composition for determination of physical state...

Of crystal or crystalline material

C436S174000, C117S011000

Reexamination Certificate

active

08080421

ABSTRACT:
The present disclosure provides a method to allow a user to pre-screen numerous crystallization conditions in the crystallization space to identify those conditions with the highest probability of yielding crystals and high quality diffracting crystals. In one embodiment, the dilute solution thermodynamic virial coefficient, termed B, is used to aid in the determination crystallization conditions that increase the probability of producing crystals for the crystallant of interest. The present disclosure also provide methods for predicting solution conditions that generate beneficial solubility and/or stability conditions for a polypeptide of interest using the B parameter. Devices for use in the described methods are also described.

REFERENCES:
patent: 6974678 (2005-12-01), Wilson et al.
patent: 2004/0129199 (2004-07-01), Hamrick et al.
DeLucas et al., “Protein crystallization: virtual screening and optimization”, Progress in Biophysics and Molecular Biology, 88, 285-309 (2005).

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