Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1983-07-20
1986-01-14
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514458, 514725, 514861, 514863, A61K 3578, A61K 31355, A61K 3107
Patent
active
045645221
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
This invention relates to pharmaceutical preparations and compositions, particularly but not exclusively for external application to provide symptomatic relief of dermatological conditions, e.g. excema, psoriasis, herpes simplex (cold sores) and the like; and their manufacture.
DISCLOSURE OF INVENTION
According to this invention there is provided a pharmaceutical composition characterised in that it comprises
(a) Vitamin A,
(b) one or more tochopherols
(c) an oil of the genus prunus, and
(d) an oil of the genus sesamum, weight of (a); in that the weight of each of (c) and (d) is between 4 and 125 times the weight of (b); in that the composition has a consistency suitable for topical application in that the genus prunus consists of five members, viz. prunus communis (almond), prunus armeniaca (apricot), prunus persica (peach), prunus domestica (plum) and prunus cerasus (cherry); and in that the genus sesamum consists of three members, viz. sesamum indicum, ceratotheca sesamoides and sesamum angustifoloum.
Advantageously the ratio of the weight of (a) to (b) is in the range 1:15.5 to 21:1. Preferably the weight of (a) is between 0.75 and 1.8 times the weight of (b).
Preferably the weights of (a) and (b) are substantially the same.
Preferably the weights of (c) and (d) are substantially the same.
Preferably the weight of (c)--or (d)--is approximately 18 to 19 times the weight of (a) and approximately 20 times the weight of (b).
In preferred examples of this invention, (c) comprises almond oil and (d) comprises sesame seed oil.
Advantageously said preparation or composition further comprises olive oil, the weight of olive oil being preferably between 9 and 140 times the weight of (a) and/or between 7 and 250 times the weight of (b).
Preferably said Vitamin A is in the form of the resin palmitate.
BEST MODE OF CARRYING OUT THE INVENTION
Various preferred embodiments of this invention will now be described, reference being had to Table A.
In all these preferred embodiments of Table A, the Vitamin A employed is in the form of the palmitate resin oil with a strength of 1.times.10.sup.6 International Units per gm of the oil. The palmitate Vitamin A alone has a strength of 1.87.times.10.sup.6 International Units per gm whence it will be appreciated that the weight figures for constituent (a) in columns I, II, III and IV of Table A corresponds respectively 4-10, 2, 10 and 5 ml of the said palmitate resin oil.
In these preferred embodiments of Table A, the Vitamin E employed constitutes and is provided by a mixture of tochopherols--typically 10-15% alpha-tochopherols, 64-76% of a combination of beta-tochopherols and gamma-tochopherols, and 20-30% delta-tochopherols. For the purposes of these examples, the reference to Vitamin E is to be taken as a reference to the whole mixture of tochopherols employed rather than, for example, to just the alpha-tochopherols (which are considered by some authorities to be the essential substance to which the term Vitamin E may be employed). For the composition of column II of Table A, the Vitamin E employed was in an oil form known as T.sub.30, i.e. having 300 mg of tochopherols per ml of oil, and the indicated weight of 0.6 g therefore corresponds to 2 ml of the oil T.sub.30. For the composition of column III of Table, the Vitamin E employed was in an oil form known as T.sub.70, i.e. having 700 mg of tochopherols per ml of oil, and the indicated weight of 7 g therefore corresponds to 10 ml of the oil T.sub.70. For the compositions of columns I and IV of Table A, the Vitamin E employed was in an oil form known as T.sub.50 (e.g. that sold under the Trade Mark "COVIOX T.sub.50 "), i.e. having 500 mg of tochopherols per ml of oil, and the indicated weights of 2-5 g and 2.5 g therefore correspond to respectively 4-10 ml and 5 ml of the oil T.sub.50.
TABLE A __________________________________________________________________________
Composition
I II III IV
Constituent g % g % g % g %
________________________________________________________________________
REFERENCES:
patent: 3943248 (1976-03-01), Shulman
Chem. Abst. 9471275v, Refining Peach Oil, 1981.
Modern Drug Encyclopedia, 9th ed., 1963, p. 1420, "Tocophrin Injection".
Goldberg Jerome D.
Kreske Walter J.
Rollins John W.
Shelleden Products Limited
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