Treating cardiovascular disease with TRPC3 channel protein

Details Treating cardiovascular disease with TRPC3 channel protein Treating cardiovascular disease with TRPC3 channel protein

2010-10-05

2011-10-04

Li, Ruixiang (Department: 1646)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

08030276

ABSTRACT:
The invention refers to the use of a TRPC channel, an inactivating mutant thereof, or a nucleotide sequence coding for the TRPC channel or for the inactivating mutant for the production of a medicament for the treatment of a cardiovascular disease and a method of screening a modulator of the TRPC channel or an inactivating mutant thereof.

REFERENCES:
patent: 2005/0182011 (2005-08-01), Olson et al.
patent: WO02/059155 (2002-08-01), None
patent: WO02/072824 (2002-09-01), None
patent: WO2005/049084 (2005-06-01), None
Bergdahl et al., Cholesterol depletion impairs vascular reactivity to endothelin-1 by restoring store-operated Ca2+ entry dependent on TRPC1 , Circulation Research, vol. 93, No. 9, Oct. 31, 2003, pp. 839-847.
Golovina et al., Upregulated TRP and enhanced capacitative Ca2+ entry in human pulmonary artery myocytes during proliferation, Am J. Physiol Heart Circ Physiol, vol. 280, 2001, pp. H746-H755.
Zhu et al., Receptor activated Ca2+ influx via Human Trp3 Stably Expressed in Human Embryonic Kidney (HEK)293 Cells, J. of Biol. Chem., vol. 273, No. 1, Jan. 2, 1998, pp. 133-142.
Hofmann et al., Subunit composition of mammalian transient receptor potential channels in living cells, PNAS USA, vol. 99, No. 11, May 28, 2002, pp. 7461-7466.
Strubing et al., Formation of novel TRPC channels by complex subunit interactions in embryonic brain, J. of Biological Chemistry, vol. 278, No. 40, Oct. 3, 2003, pp. 39014-39019.
Vandebrouck et al., Involvement of TRPC in the abnormal calcium influx observed in dystrophic (mdx) mouse skeletal muscle fibers, J. of Cell Biology, vol. 158, No. 6, Sep. 16, 2002. pp. 1069-1096.
Yip et al., Expression of TRPC homologs in endothelial cells and smooth muscle layers or human arteries, Histochemistry and Cell Biology, vol. 122, No. 6, Dec. 2004, pp. 553-561.
Groschner et al., Trip proteins form store-operated cation channels in human vascular endothelial cells, FEBS Letters, vol. 437, No. 1-2, Oct. 16, 1998, pp. 101-106.

Affiliated with

Also associated with

Rating

Treating cardiovascular disease with TRPC3 channel protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treating cardiovascular disease with TRPC3 channel protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treating cardiovascular disease with TRPC3 channel protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4301069