Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2010-11-03
2011-10-04
Saeed, Kamal (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
active
08030486
ABSTRACT:
The present invention provides with a process of preparing an optically active succinimide derivative, which is a key intermediate for production of ranirestat. A compound (3) is easily prepared by treating the derivative of succinic acid diester of the formula (2):wherein R1is an amino group protected with a group removed by hydrogenolysis or a tert-butoxycarbonylamino group and R2is an ethyl group optionally substituted with one or two methyl group(s) at α-position, provided that R2is not a tert-butyl group when R1is a tert-butoxycarbonylamino group; with alkali metal alkoxide and the compound (3) can be an important intermediate for production of ranirestat.
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Inagaki Takashi
Yamakawa Yoshikazu
Dainippon Sumitomo Pharma Co. ,Ltd.
Grazier Nyeemah A
Katayama Seiyakusyo Co. Ltd.
Saeed Kamal
Wenderoth , Lind & Ponack, L.L.P.
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