Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2004-07-05
2011-11-15
Jarrell, Noble (Department: 1622)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
active
08058436
ABSTRACT:
The invention provides a method for the preparation of enantiomerically pure mirtazapine, said method comprising a step of ring closure of a compound of formula (II) wherein X is a leaving group, said step comprising treatment with an acid, whereby mirlazapine with enantiomeric excess is formed by the ring closure of the compound of formula (II) with enantiomeric excess by treatment with a suitable acid in the absence of a solvent or a suitable combination of an acid and an organic solvent.
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Kemperman Gerardus Johannes
Van De Ven Adrianus Antonius Martinus
Wieringa Johannes Hubertus
Devlin Gerard M.
Hess Susan L.
Jarrell Noble
N.V. Organon
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