Method of treating ocular allergy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S546000, C514S558000

Reexamination Certificate

active

08034839

ABSTRACT:
The topical use of 5,6,7-trihydroxyheptanoic acid and analogs alone or in combination with histamine antagonists and/or mast cell stabilizers is disclosed for the treatment of ocular allergy.

REFERENCES:
patent: 5079261 (1992-01-01), Serhan et al.
patent: 6645978 (2003-11-01), Gamache et al.
patent: 2006/0058375 (2006-03-01), Klimko et al.
patent: 2006/0099248 (2006-05-01), Klimko et al.
patent: 2006/0154981 (2006-07-01), Klimko et al.
patent: 2008/0108695 (2008-05-01), Klimko et al.
patent: W003040080 (2003-05-01), None
patent: WO03039533 (2003-05-01), None
patent: WO2005112905 (2005-12-01), None
patent: WO2006052950 (2006-05-01), None
Leonard Bielory, et al., “Efficacy and Tolerability of Newer Antihistamines in the Treatment of Allergic Conjunctivitis,” Drugs, 2005, pp. 215-228, vol. 65(2).
C. Bonnans, et al., “Lipoxins in asthma: potential therapeutic mediators on bronchial inflammation?” Allergy, 2004, pp. 1027-1041, vol. 59.
Nan Chiang, et al., “Activation of Lipoxin A4 Receptors by Aspirin-triggered Lipoxins and Select Peptides Evokes Ligand-specific Responses in Inflammation,” J. Exp. Med., Apr. 3, 2000, pp. 1197-1207, vol. 191, No. 7.
Stefano Fiore, et al., “Identification of a Human cDNA Encoding a Functional High Affinity Lipoxin A4 Receptor,” J. Exp. Med., Jul. 1994, pp. 253-260, vol. 180.
Stefano Fiorucci, et al., “A β-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction,” Proc. Nat. Acad. Sci., Nov. 2004, pp. 15736-15741, vol. 101, No. 44.
Felicity N. E. Gavins, et al., “Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related ani-inflammatory mechanisms,” Blood, May 15, 2003, pp. 41404147, vol. 101, No. 10.
Derek W. Gilroy, et al., “Inflammatory Resolution: New Opportunities for Drug Discovery,” Nature Reviews, May 2004, pp. 401-416, vol. 3.
Karsten Gronert, et al., “Selectivity of Recombinant Human Leukotriene D4, Leukotriene B4, and Lipoxin A4 Receptors with Aspirin-Triggered 15-epi-LXA4 and Regulation of Vascular and Inflammatory Responses,” American Journal of Pathology, Jan. 2001, vol. 158, No. 1.
Karsten Gronert, et al., “A role for the Mouse 12/15-Lipoxygenase Pathway in Promoting Epithelial Wound Healing and Host Defense,” Apr. 5, 2005, 15267-15278, vol. 280, No. 15.
William J. Guilford, et al., “Novel 3-Oxa Lipoxin A4 Analogues with Enhanced Chemical and Metabolic Stability Have Anti-inflammatory Activity in Vivo,” J. Med. Chem., 2004, pp. 2157-2165, vol. 47.
Levente Jozsef, et al., “Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kB and AP-1 activitation, and IL-8 gene expression in human leukocytes,” Proc. Nat. Acad. Sci., Oct. 1, 2002, pp. 13266-13271, vol. 99, No. 20.
Christopher L. Karp et al., “Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway,” Nature Immunology, Apr. 2004, pp. 388-392, vol. 5, No. 4.
Yingying Le, et al., “Pleiotropic roles of formyl peptide receptors,” Cytokine and Growth Factor Reviews, 2001, pp. 91-105, vol. 12.
Tak H. Lee, et al., “Inhibition of Leukotriene B4-Induced Neutrophil Migration by Lipoxin A4: Structure-Function Relationships,” Biochemical and Biophysical Research Communications, Nov. 14, 1991, pp. 1416-1421, vol. 180, No. 3.
Bruce D. Levy, et al., “Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4,” Nature Medicine, Sep. 2002, pp. 1018-1023, vol. 8, No. 9.
King-Teh Lin, et al., “Modulation of LTB4 Receptor in T-Lymphocytes by Lipoxin A4 (LXA4) and its Role in Delayed-Type Hypersensitivity,” Advances in Experimental Medicine and Biolog 1999 pp. 151-163, vol. 447.
Christianne Bandeira-Melo, et al., “Cutting Edge: Lipoxin (LX) A4 and Aspirin-Triggered 15-Epi-LXA4 Block Allergen-Induced Eosinophil Trafficking,” J. of Immunology , 2000, pp. 2267-2271, vol. 164.
Santa Jeremy Ono, et al., “Allergic conjunctivitis: Update on pathophysiology and prospects for future treatment,” J. Allergy Clin Immunol., 2005, pp. 118-122, vol. 115.
Luca Parente, et al., “Annexin 1: more than an anti-phospholipase protein,” Inflammation Res., pp. 125-132, vol. 53.
Mauro Perretti, et al., “Endogenous lipid-and peptide-derived anti-inflammatory pathways operated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor,” Nature Medicine, Nov. 2002, pp. 1296-1302, vol. 8, No. 11.
Nicos A. Petasis, et al., “Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins,” Prostaglandins, Leukotrienes, and Essential Fatty Acids, 2005, pp. 301-321, vol. 73.
Arndt J. Schottelius, et al., “An Aspirin-Triggered Lipoxin A4 Stable Analog Displays a Unique Topical Anti-Inflammatory Profile,” J. of Immunology 2002, pp. 7063-7070, vol. 169.
Isabelle Vachier, et al., “Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound,” J. Allergy Clin. Immunol. 2005, pp. 65-60, vol. 115.
Mitchell H. Friedlaender, “Conjunctivitis,” The Merck Manual of Patient Symptoms (retrieved from Internet: URL:http://www.merck.com/mmpe/sec09/ch101/ch101c.html), Jun. 2008.
PCT/US2010/02351, International Search Report, Date of Mailing: Jun. 2, 2010.

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