Method of detecting the cystic fibrosis transmembrane...

Details Method of detecting the cystic fibrosis transmembrane... Method of detecting the cystic fibrosis transmembrane...

2004-05-20

2011-12-13

Bunner, Bridget E (Department: 1647)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S325000, C435S320100, C536S023100

Reexamination Certificate

active

08076101

ABSTRACT:
The present invention provides a recombinant nucleic acid encoding a modified cystic fibrosis transmembrane conductance regulator (CFTR) protein. The nucleic acid is modified by the insertion of a first heterologous segment encoding a detectable epitope in a region encoding an extracytoplasmic loop, such as at least one of EL1 through EL6. E12 is currently preferred. Proteins encoded by such nucleic acids, vectors and cells containing such nucleic acids, and methods of use thereof are also described.

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